HCRI maintains unique collaborations with academic based faculty within and beyond the Harvard Medical community.

As an Academic Research Organization, HCRI combines the logistical capabilities and efficiencies necessary to run and manage large multi-center clinical trials leveraging the world-class scientific leadership necessary to produce analysis that will maximize the visibility and value of each clinical trial. HCRI supports the research efforts of its affiliated physicians allowing them to become more widely published.

HCRI physicians and research professionals have substantial experience in clinical research, including managing multi-center clinical trials through many years of close collaboration with industry sponsors, the National Institutes of Health and the Food and Drug Administration. HCRI’s clinical trial design, study execution and data analysis expertise spans multiple therapeutic specialties, such as cardiology, central nervous system, pulmonology, as well as orthopedics and nephrology. Research sponsors include pharmaceutical, biopharmaceutical and medical device companies, government agencies and private foundations.  

In addition to facilitating collaboration between industry and academic researchers, HCRI is a leader in the design and conduct of high-quality, large-scale public health studies, such as the DAPT Study and the AHRQ-funded BELT Study. HCRI thrives on projects that will help answer important questions facing the healthcare system, and works closely with study sponsors to answer significant public health questions in order to improve treatment guidelines and patient care.

The results of HCRI’s research speak to its success. The Institute has assisted in the analysis of data for numerous regulatory submissions in the US and abroad.  HCRI has managed hundreds of clinical research trials collecting data on over 140,000 patients. Manuscripts from data collected and analyzed by HCRI have been published in hundreds of peer-reviewed journals.

HCRI also offers Fellowship programs, specifically working with Beth Israel Deaconess Medical Center (BIDMC), Division of Cardiology and Massachusetts General Hospital (MGH), Department of Psychiatry. The main goals of the programs are to help advance the study of structural heart disease and psychiatry as well as train physicians for careers in clinical research. To learn more about these programs, check out our Fellowships.

Latest Publications

Transcatheter Interatrial Shunt Device for the Treatment of Heart Failure: Rationale and Design of the Randomized Trial to REDUCE Elevated Left Atrial Pressure in Heart Failure (REDUCE LAP-HF I).

Heart failure with preserved ejection fraction (HFpEF), a major public health problem with high morbidity and mortality rates, remains difficult to manage because of a lack of effective treatment options. Feldman T 1 , Komtebedde J 2 , Burkhoff D 2…

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Frequency of Stent Thrombosis Risk at 5 Years in Women Versus Men With Zotarolimus-Eluting Compared With Sirolimus-Eluting Stent

The prevalence of factors that are associated with an increased risk of stent thrombosis (ST), including smoking, diabetes mellitus, and small stent size, is different in women and men who underwent percutaneous coronary intervention. Ten Haaf M 1 ,…

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