DAPT Trial Secondary Analysis highlighting whether the risks of stent thrombosis (ST) and major adverse cardiovascular and cerebrovascular events (MACCE) differ from BMS and DES as well as whether the optimal duration of DAPT therapy differs for BMS and DES
The Harvard Clinical Research Institute (HCRI) announced today results of the DAPT Study, a major international study that investigated the duration of dual antiplatelet therapy (DAPT, the combination of aspirin and a thienopyridine/antiplatelet medication to reduce the risk of blood clots) following coronary stent implantation.
Congratulations to HCRI faculty member Dr. Alex Turchin, who was recently accepted as a fellow in the American College of Medical Informatics (ACMI).
DAPT Study Presentations at AHA
Cost Effectiveness of Self-Expanding Valve Driven by Improved Quality of Life Benefit and Superior One-Year Survival Rates over Surgical Aortic Valve Replacement. WASHINGTON, D.C., and MINNEAPOLIS – Sept. 13, 2014 – In the first-ever in-trial cost effectiveness analysis of transcatheter aortic valve replacement (TAVR) for patients at high risk for surgery, investigators today revealed new data demonstrating the cost effectiveness of the CoreValve® System from Medtronic, Inc. (NYSE: MDT) for high risk patients with severe aortic stenosis. The economic analysis used data from the CoreValve U.S. Pivotal Trial’s study of high risk patients, which is the only head-to-head study to show the superiority of TAVR to traditional surgical aortic valve replacement (SAVR) at one year. The new data were presented during a late-breaking session at Transcatheter Cardiovascular Therapeutics (TCT) 2014.
BARCELONA, Spain – Sunday 31 August: The investigational drug alirocumab significantly improved cholesterol levels compared to ezetimibe, when added to regular statin therapy in patients with high cholesterol and elevated risk of cardiovascular disease (CVD), according to the ODYSSEY COMBO II trial, presented as a Hot Line today at ESC Congress 2014.
A new study from HCRI highlights the importance of post market surveillance stent studies to depict safety signals. Postmarket surveillance of zotarolimus-eluting stents shows similar efficacy compared with premarket studies despite differences in patient populations but finds higher risk of myocardial infarction (MI), according to a paper published online June 9, 2014, in the American Journal of Cardiology.